Beilstein J. Org. Chem.2021,17, 334–342, doi:10.3762/bjoc.17.31
pyrrolizidines; cyanoketones; legonmycin; vinylogousureas; Introduction
At least 40 members of the large class of pyrrolizidine alkaloids [1][2][3][4] have so far been characterized from bacterial cultures. Of these ‘bacterial pyrrolizidines’, those of the vinylogous urea type are particularly intriguing from
vinylogousureas, since they lack the C(1) carbonyl group, their structural relationship with bohemamine, the first genuine member of the group, qualifies them as honorary members. The structure of bohemamine, named by its discoverers at Bristol–Myers Company and Cornell University after the opera La Bohème
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Graphical Abstract
Figure 1:
The clazamycins, and selected bacterial pyrrolizidines of the vinylogous urea type. For consistency...